Example of what sizes to encode symbolic icons to (note that 22px is excluded because 16px doesn't scale well to it.)
./16×16/status/mail-unread-symbolic.symbolic.png
./16×16/status/mail-unread.png
./24×24/status/mail-unread-symbolic.symbolic.png
./24×24/status/mail-unread.png
./32×32/status/mail-unread-symbolic.symbolic.png
./32×32/status/mail-unread.png
./48×48/status/mail-unread-symbolic.symbolic.png
./48×48/status/mail-unread.png
./scalable/status/mail-unread-symbolic.svg
./64×64/status/mail-unread-symbolic.symbolic.png
./96×96/status/mail-unread-symbolic.symbolic.png